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Case Western Reserve University - 2016

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Research Description

Research Description By Graduate Engineering Department

Biomedical Engineering

Several research thrusts are available to accommodate various student backgrounds and interests. Strong research collaborations with clinical and basic science departments of the university and collaborating medical centers bring a broad range of opportunities, expertise, and perspective to student research projects.

Biomaterials/Tissue Engineering/Drug and Gene Delivery
Fabrication and analysis of materials for implantation, including neural, orthopaedic, and cardiovascular tissue engineering, biomimetic materials, liposomal and other structures for controlled, targeted drug delivery, and biocompatible polymer surface modifications. Analysis of synthetic and biologic polymers by AFM, nanoscale structure-function relationships of biomaterials. Applications in the nervous system, the cardiovascular system, the musculoskeletal system, and cancer.

Biomedical Imaging
MRI, PET, SPECT, CT, ultrasound, acoustic elastography, optical coherence tomography, cardiac electrical potential mapping, human visual perception, image-guided intervention, contrast agents. In vivo microscopic and molecular imaging, and small animal imaging.

Biomedical Sensing
Optical sensing, electrochemical and chemical fiber-optic sensors, chemical measurements in cells and tissues, endoscopy.

Big Data Analytics and Health Informatics
Radiomics, Radiogenomics, computer assisted diagnosis, digital pathology, co-registration, cancer detection, decision making, precision medicine, bioinformatics, image informatics, machine learning, pattern recognition, artificial intelligence, deep learning.

Neural Engineering and Neural Prostheses
Neuronal mechanisms; neural interfacing for electric and magnetic stimulation and recording; neural dynamics, ion channels, second messengers; neural prostheses for control of limb movement, bladder, bowel, and respiratory function; neuromodulation systems for movement disorders, epilepsy, pain mitigation, visceral functions; computational modeling and simulation of neural structures.

Transport and Metabolic Systems Engineering
Modeling and analysis of tissue responses to heating (e.g., tumor ablation) and of cellular metabolism related to organ and whole-body function in health (exercise) and disease (cardiac).

Biomechanical Systems
Computational musculoskeletal modeling, bone biomechanics, soft tissue mechanics, control of neuroprostheses for motor function, neuromuscular control systems, human locomotion, cardiac mechanics.

Cardiovascular Systems
Normal cardiac physiology, pathogenesis of cardiac diseases, cardiac development, therapeutic technologies, including cardiac regeneration; electrophysiological techniques, imaging technologies, mathematical modeling, gene regulation, molecular biology techniques; cardiac bioelectricity and cardiac biomechanics.

Chemical and Biomolecular Engineering

Research in the department is sponsored by a variety of state and federal agencies, by private industry, and by foundations. Current active research topics include:

• Novel energy storage systems for transportation, grid storage applications, and portable devices
• Energy efficient extraction and processing of materials
• Fuel cells and batteries
• Novel catalysts, electrocatalysts and plasmas for conversion of gases to fuels
• Simulation, modeling, and fundamental characterization of transport and interfacial processes in electrochemical energy storage and conversion systems
• Advanced materials for electronic and electrochemical device applications
• Novel synthesis and deposition methods and reactor designs, including electrochemical and plasma reactors
• Novel characterization of materials and in situ reactor diagnostics
• Simulation and theory of materials properties
• Surface properties and interfacial phenomena
• Materials processing and engineering at molecular through macro scales
• Novel separations processes
Biomolecular Engineering
• Biosensors
• Cell and tissue engineering
• Biocatalysis and protein engineering

Civil Engineering

Research under way in civil engineering includes work in analytical, design and experimental areas and is sponsored by industry, state, and federal government sources. Major areas of research interest are:

• Behavior of reinforced and prestressed concrete
• Wind engineering
• Earthquake analysis and design of structures
• Finite element methods
• Nondestructive Testing of Structures
• Passive control of the vibration of structures
• Transient response of nonlinear structures
• Blast loading of structures
• Fracture mechanics
• Multiscale simulation of nonlinear dynamic structural behavior
• Modeling of structural materials and structural systems
• High and low-cycle fatigue
• Geotechnical/Pavement Materials
• Static behavior of anisotropic clays and sands
• Soil liquefaction
• Centrifuge modeling of static and dynamic soil behavior
• Dynamic soil structure interaction
• Non-destructive testing evaluation of soils and pavement materials
• Measurement of dynamic soil properties
• Design of Structures for High-Speed Vehicles
• Stability of tailings dams
• Environmentally conscious manufacturing
• Brownfields/structural remediation
• Environmental modeling and software development
• Geoenvironmental engineering
• Sediment remediation
• Environmental chemistry
• Bioremediation
• Structural health monitoring
• Transportation safety
• Infrastructure engineering
• Non-destructive Testing
• Sensor technology
• Smart materials
• Energy structures and geotechnology
• Biofuel development
• Urban hydraulics
• Soil contamination standards
• Intelligent infrastructure and transportation system
• Driver safety
• Building materials
• Environmental hazard and risk engineering
• Extreme dynamic load resistant design
• Multi-hazard and structural risk assessment

Electrical Engineering and Computer Science

The research thrusts of the Electrical Engineering and Computer Science department include:

• Micro/Nano Systems
• Electronics and Instrumentation
• Robotics and Haptics
• Embedded Systems, including VLSI, FPGA
• Hardware Algorithms, Hardware Security, Testing/Verification
• Bioinformatics and Systems Biology
• Machine Learning and Data Mining
• Computer Networks and Distributed Systems
• Secure and Reliable Software
• Energy Systems, including Wind and Power Grid Management/Control
• Gaming, Simulation, Optimization
• Medical Informatics and Wireless Health

EECS participates in a number of groundbreaking collaborative research and educational programs, including the Microelectromechanical Systems Research Program, the Center for Computational Genomics, graduate program in Systems Biology and Bioinformatics, the Clinical & Translational Science Collaborative, the Great Lakes Energy Institute, and the VA Center for Advanced Platform Technology.

Macromolecular Science and Engineering

The research activities of the department span the entire scope of macromolecular science and polymer technology.

New types of macromolecules are being made in the department’s synthesis laboratories. The emphasis is on creating polymers with novel functional properties such as photoconductivity, selective permeation, and biocompatibility, and in producing new materials which behave like classical polymers without being linked together by covalent bonds.

Physical Characterization
This is the broad area of polymer analysis, which seeks to relate the structure of the polymer at the molecular level to the bulk properties that determine its actual or potential applications. This includes characterization of polymers by infrared, Raman, and NMR and mass spectroscopy, thermal and rheological analysis, determination of structure and morphology by x-ray diffraction, electron microscopy, and atomic force microscopy, permeability and free volume, and investigation of molecular weights and conformation by light scattering.

Mechanical Behavior and Analysis
Polymeric materials are known for their unusual mechanical capabilities, usually exploited as components of structural systems. Analysis includes the study of viscoelastic behavior, yielding and fracture phenomena and a variety of novel irreversible deformation processes.

A major concern of industry is the efficient and large scale production of polymer materials for commercial applications. Research in this area is focusing on reactive processing, multi-layer processing and polymer mixing, i.e., compounding and blends. The integration of sensors and processing equipment, and methods for examining changes in structure and composition during processing steps are growing areas of inquiry. Both laboratory and simulation research are brought to bear on these critical issues.

Materials Development and Design
Often, newly conceived products require the development of polymeric materials with certain specific properties or design characteristics. Materials can be tailor-made by designing synthesis and processing conditions to yield the best performance under specified conditions. Examples might be the design of photoluminescent and semi-conducting polymers for use in optoelectronic devices, polymers that are stable at high temperatures for fire-retardant construction materials, high temperature polymer electrolytes for use in advanced fuel cells, low density thermal insulating polymer composite materials, advanced polymeric optical devices, and biocompatible polymers for use in prosthetic implants, reconstructive medicine and drug-delivery vehicles.

Living systems are composed primarily of macromolecules, and research is in progress on several projects of medical relevance. The department has a long-standing interest in the hierarchical structure and properties of the components of connective tissues (e.g., skin, cartilage, and bone). The department is also engaged in the development of new biocompatible polymers for applications in human health.

Materials Science and Engineering

Department research areas include:

Deformation and Fracture
Relationships between structure and mechanical behavior of traditional and advanced materials: metals, ceramics, intermetallics, composites, and biological materials. State-of-the art facilities are available for deformation processing as well as mechanical testing over a range of strain rates, test temperatures, stress states, and size scales for both monotonic and cyclic conditions.

Materials Processing
Alloy surface engineering, crystal growth, thin- film deposition, casting of metal alloys, metallic glasses by rapid solidification, powder synthesis, crystallization of amorphous alloys, consolidation processing, layered materials, plated metals and alloys, solution- and/or precipitation heat-treatments, thermo-mechanical processing, diffusion-bonding, brazing and welding of metals, glasses and ceramics, electro-chemical and thermo-chemical oxidation/reduction conversion processing of metal/oxide surface layers.

Environmental Effects
Durability and lifetime extension of structural, energy-conversion and energy-storage materials including materials for solar energy. Corrosion, oxidation, stress-corrosion, low-and high-cycle fatigue, adhesion, decohesion, friction and wear. Surface modification and coatings, adhesion, bonding, and dis-bonding of dissimilar materials, reliability of electronics, photonics and sensors.

Surfaces and Interfaces
Material surfaces in vacuum, ambient and chemical environments, grain-and phase boundaries, hetero-interfaces between different metals, ceramics, carbon (graphite) and polymers.

Electronic, Magnetic, and Optical Materials
Materials for energy technologies, such as photovoltaics, organic and inorganic light emitting diodes and displays, fuel cells, electrolytic capacitors, building-envelope materials, and wind turbines. Processing, properties, and characterization of magnetic materials and ferroelectric and piezoelectric ceramics.

Microcharacterization of Materials
Facilities for high-resolution imaging, spatially resolved chemical analysis, and diffractometry. Conventional, analytical, and high-resolution transmission electron microscopy, scanning electron microscopy, focused ion beam techniques, scanning probe microscopy, light-optical microscopy, optical spectroscopies, surface analysis, and X-ray diffractometry.

Mechanical and Aerospace Engineering

Research areas include:

Aerospace Technology and Space Exploration
Flow in turbomachinery, molecular dynamics simulation of rarefied gas flow, two phase flow, supersonic combustion and propulsion, thermoacoustic refrigeration, in-situ resource utilization from space. Gravitational effects on transport phenomena, fluids and thermal processes in advance life support systems for long duration space travel, interfacial processes, g-jitter effects on microgravity flows, two phase flow in zero and reduced gravity.

Combustion and Energy
Hydrogen ignition and safety, catalytic combustion, flame spread, fire research and protection, combustion in micro- and partial gravity.

Data Analytics
Multi-domain signal decomposition and analysis, wavelet transform and other transformation methods, data fusion, statistical methods for defect detection, root cause diagnosis, and remaining service life prognosis, multi-scale analysis.

Dynamics of Rotating Machinery
Forced and instability vibration of rotor/bearing/seal systems, nonlinear rotor dynamics, torsional rotor vibration, rotor dynamic characteristics of bearings and seals (computational and experimental approach), control of rotor system dynamics, rub-impact studies on bearings and compressor/turbine blading systems. Advanced rotating machinery monitoring and diagnostics.

Engineering Design
Optimization and computer-aided design, feasibility studies of kinematic mechanisms, kinematics of rolling element-bearing geometries, mechanical control systems, experimental stress analysis, failure analysis, development of biologically inspired methodologies.

Heat Transfer
Analysis of heat transfer in complex systems such as biological organisms, multi-functional materials and building enclosures.

Agile manufacturing work cells developed to facilitate quick change over from assembly of one object to assembly of other objects contains multiple robots, a conveyor system and flexible parts feeders. Additive manufacturing, in-process sensing and control.

Development of novel experimental techniques to investigate material response at elevated temperatures and high rates of deformation. Constitutive modeling of damage evolution, shear localization and failure of advanced engineering materials. Fabrication of mechanical properties of composite materials; creep, rupture, and fatigue properties of engineering materials at elevated temperatures.

Multiphase Flow
Application of non-intrusive laser based diagnostic techniques and ultrasound techniques including pulsed ultrasound Doppler velocimetry to study solid-liquid, solid-gas, liquid-gas and solid-liquid-gas, multiphase flows encountered in slurry transport and bio-fluid mechanics.

Research related to various nanotechnology applications with particular emphasis on energy conversion, generation and storage in nanostructured materials including the synthesis of polymer-based nanocomposites. Current research projects include investigation of nanocomposites for thermoelectric devices, molecular simulation of thermal transport across interfacial regions, and biomimetic research on protein-based shark gel.

Musculoskeletal Mechanics and Materials
Design, modeling, and failure analysis of orthopaedic prostheses and material selection; mechanical properties of, and transport processes in, bone and soft tissue; tribology of native and tissue engineered cartilage; nondestructive mechanical evaluation of tissue engineered cartilage.

Biologically inspired and biologically based design and control of legged robots. Dynamics, control and simulation of animals and robots. Distributed intelligence, swarm robotics, social robots, wearable telesensors, tangible game interface,

Sensing and Metrology
Signal transduction mechanisms, design, modeling, behavior characterization, and performance evaluation of mechanical, thermal, optical, and magnetic-field sensors, multi-physics sensing, and precision instrumentation.

Tribology and Seals
Time-resolved friction on nano- and microsecond time scale with applications to high speed machining and mechanics of armor penetration. Study of gas lubricated foil bearing systems with application to oil-free turbomachinery. Evaluation of advanced seal concepts and configurations for high temperature applications in gas turbine engines.

Vibration characteristics of seals and bearings and measurement of chaotic motion. Rub impact studies of blade tip/casing interactions, particle-blade/casing interactions in centrifugal pumps.

Research Description By Engineering Research Center

Advanced Manufacturing and Mechanical Reliability Center

The Advanced Manufacturing and Mechanical Reliability Center (AMMRC) was originally established as the Center for Mechanical Characterization of Materials (CMCM) in 1987. This has been expanded to provide advanced manufacturing (e.g. deformation processing, extrusion, forging, forming, etc.) and mechanical characterization (e.g. mechanical testing, reliability testing, fatigue, etc.) expertise to the Case Western Reserve University campus, medical, industrial, legal, outside university and government laboratory communities. The center, housed in the Charles M. White Metallurgy building, currently maintains equipment valued in excess of $4.5M and has been accessed by the local, national and international communities. In general, the center is capable of deformation processing and/or mechanically evaluating materials that range in size scale from the micrometer range up through bulk quantities. Materials systems that have been investigated span the range of organic and inorganic materials, including metals, ceramics, polymers, composites, electronic materials and biomedical materials systems.

Advanced Platform Technology Center

The Advanced Platform Technology (APT) Center at the Louis Stokes Cleveland Veterans Affairs Medical Center (LSCVAMC) is one of 15 designated Centers in the Rehabilitation Research and Development (RR&D) Service. Established in 2005 as a collaboration between the LSCVAMC and Case Western Reserve University (CWRU), the APT Center focuses on addressing the pressing medical needs of veterans with sensorimotor dysfunction, cognitive impairment or limb-loss through the application of cutting edge technologies or rehabilitation techniques and translating them from proof of concept to viable clinical options. The APT Center captures advances in material science, microfabrication and microsystem design, neural engineering, mechanics and communications, and integrates them for applications in prosthetics/orthotics, neural interfacing, wireless health monitoring and maintenance and all forms of enabling and emerging technologies. Approximately 55 Engineers and Clinician Scientists at the LSCVAMC, CWRU, Cleveland Clinic, Cleveland State University, Kent State University, University of Michigan and Cornell University are affiliated with the APT Center and contribute to its mission. The APT Center is able to provide or facilitate access to the following resources:

• Neural modeling and analysis of interface designs 
• Polymer and bioactive material development
• Microelectromechanical (MEMS) systems design and fabrication
• 3-D and laser printing/prototyping, mechanical testing and dynamic simulation 
• Pre-clinical in vitro and in vivo verification of device performance
• Circuit, sensor and software design and fabrication 
• System validation and design control documentation
• Professional engineering support and project management
• Administrative support for intellectual property protection, regulatory affairs, and quality systems.

Case Metal Casting Laboratory

The Case Metal Processing Laboratory (CMPL) collaborates with federal agencies, industry, professional societies and associations, national laboratories and other universities to promote and advance metal processing technologies by conducting cutting edge research and development. As a Case Western Reserve University operated unit, the CMPL has an educational orientation, providing undergraduate and graduate-level training in metal processing. CWRU is both a Foundry Educational Foundation Affiliated School and a Forging Industry Association Magnet School.

Center for Advanced Polymer Processing

CAPP, the Center for Advanced Polymer Processing, stems from a partnership between Case Western Reserve University, Thermo Scientific and leading plastics and rubber companies. It is a state-of-the-art center for advanced polymer blending and compounding and reactive extrusion able to perform basic non-competitive research and development in the area of materials development and manufacturing by intent in support of the polymer, pharmaceutical and food industries.

Center for Advanced Science and Engineering of Carbon

The Center of Advanced Science and Engineering for Carbon (Case4Carbon) is a world-renowned research center at Case Western Reserve University in Cleveland, Ohio, dedicated to advances in all aspects of science and engineering for carbon.
Our mission is to pursue an integrated science and engineering program by utilizing emerging carbon nanotechnology to develop new materials, devices and systems.
One of our unique strengths is applying advanced synthetic methods to the development of advanced carbon nanomaterials with well-defined, multidimensional structures for multifunctional applications, including electrochemical energy conversion and storage.

Center for Applied Polymer Research

The Center for Applied Polymer Research (CAPRI) is a state-of-the-art center for advanced polymer blending and compounding and reactive extrusion able to perform basic research and applied research and development in support of the polymer, pharmaceutical and food industries. The main tools of CAPRI are:

**state-of-the-art sensors that allow multiple rheological, physical, chemical and morphological quantities to be measured along the screw axis of twin-screw extruders;
**advanced multi-scale computational simulation capabilities to build physical-chemical-structural models of polymer systems under flow in realistic polymer transformation processes;
**integration of on-line sensors and multi-scale softwares to develop new advanced and functional multiphase complex materials or optimize the performance of existing ones.

Center for Biomaterials

The Center for Biomaterials carries out research and development projects to investigate new biomaterials, tissue-engineered materials, and targeted drug-delivery systems for use in cardiovascular applications and implants.

The Center for Biomaterials also provides researchers access to shared-use facilities, which includes high-resolution microscopy such as AFM, molecular spectroscopies, surface analysis, and polymer and peptide synthesis capabilities. The chemical and mechanical interface between the biomaterial and the host tissue are the focus of major study, with the goals being to improve biologic function and biocompatibility in the response of the human body to implants.

Current projects include investigation of thrombosis (blood clotting) and infection mechanisms due to cardiovascular prosthesis, biomimetic design of novel biomaterials for cardiovascular and neural implants; and cardiovascular and neural tissue engineering based on biomimetic designs. Studies at the cell and molecular level assist our understanding of the underlying mechanisms so that novel biomedical materials may be designed, prepared and characterized.

Center for Computational Imaging and Personalized Diagnostics

The Center of Computational Imaging and Personalized Diagnostics at Case Western Reserve University is involved in various different aspects of developing, evaluating and applying novel quantitative image analysis, computer vision, pattern recognition and machine learning tools for disease diagnosis, prognosis and theragnosis in the context of several oncologic (e.g. breast, prostate, brain, lung, rectal, head&neck) as non-oncologic diseases (e.g. plaque, epilepsy, inflammatory bowel disease). Our group is also exploring the utility of these methods in studying correlations of disease markers across multiple length scales, modalities, and functionalities"from gene and protein expression to spectroscopy to digital pathology and to multi-parametric MRI and CAT scans. We also work closely with industry to move a number of the technologies towards translation and commercialization.

Center for Evaluation of Implant Performance

The mission of the Center for the Evaluation of Implant Performance is to pursue engineering and scientific analysis of retrieved joint reconstruction devices and to evaluate the performance of implants during patient use. This mission is achieved through IRB-approved collection, maintenance, and protection of clinical and radiographic information and total joint replacement components obtained at revision or removal surgery. The goal is to advance the science of joint replacement durability and improved performance for better patient outcomes through improvements in implant materials and design. To this end, the Center for the Evaluation of Implant Performance works in partnership with the Center for Joint Replacement and Restoration at University Hospitals Cleveland Medical Center.

Center for Layered Polymeric Systems

The Center for Layered Polymeric Systems (CLiPS) is an NSF Science & Technology Center and focuses its intensive research on microlayering and nanolayering process technology and draws strength from Case Western Reserve's extensive history in polymer science.

Technology refined within CLiPS allows the production of films and membranes composed of hundreds or thousands of layers. These extremely thin layers promote interactions approaching the molecular level between the materials used in the process.

CLiPS research activities are organized into five platforms to exploit the microlayer and nanolayer structures:
(1) Rheology and New Processing focuses on integrating rheology into the multilayering process, and explores combinations of rheologically dissimilar materials to create new polymer-based structures;
(2) advanced Membranes and Transport Phenomena that exploit the layered hierarchy to achieve unique transport properties;
(3) novel Optic and Electronic Systems based on the advanced layered materials;
(4) Science and Technology Initiatives that probe a fundamental understanding and explore new opportunities for the layered structures, and
(5) new Templated Interfaces and Reactions that explores chemistry using templates, interfaces, and patterning to discover new phenomena and introduce new or responsive properties in multilayer films.

Cleveland Functional Electrical Stimulation Center

The Cleveland Functional Electrical Stimulation Center builds upon the neural engineering accomplishments of the Department of Biomedical Engineering and several clinical partners to develop electrode stimulation systems that restore movement, relieve pain, enhance neurological rehabilitation, treat autonomic disorders, and mitigate psychiatric conditions. These systems apply electrical currents to either generate or suppress activity in the nervous system to compensate for disease or injury.

The center focuses its activities in four major areas:
**Fundamental studies to discover new knowledge
**Enabling technologies for clinical application or the discovery of knowledge
**Clinical research that applies this knowledge and technology to individuals with neurological dysfunction
**Transfer of knowledge and technology to the clinical community and to industry.

Control and Energy Systems Center

With an interdisciplinary and concurrent engineering approach, the Control and Energy Systems Center (CESC) focuses on bridging the gap between fundamental research and applied industrial projects in Advanced Control and Systems Engineering, with special emphasis in energy innovation, wind energy, power systems, water treatment plants, sustainability, spacecraft, environmental and industrial applications. Fundamental research is conducted to gain knowledge and understanding on multi-input-multi-output systems, distributed parameter systems and nonlinear plants with uncertainty, and to develop new methodologies to design quantitative robust controllers to improve the efficiency and reliability of such systems.

The CESC’s expertise has been applied to real-world problems with industrial partners and space agencies in the following main areas:

Multi-Megawatt Onshore and Offshore Wind Turbines
Airborne Wind Energy Systems
Renewable Energy Plants, Advanced Energy Systems
Power System Dynamics and Control, Grid Integration, Energy Storage
Large Radio Telescope Control, Optical Telescope Control
Formation Flying Spacecraft, Satellites with Flexible Appendages
Wastewater Treatment Plants, Desalination Systems
Heating Systems, Fluid Dynamics
Robotics, Parallel Kinematics

The CESC's capabilities and equipment include:

Fully instrumented wind tunnel to test prototypes at wind speeds up to 20 m/s
Lab-scale wind turbine blade manufacturing units
State-of-the-art computer programs for commercial wind turbine design
Aerodynamics, Solid modeling and Electrical design CAD/CAE software
Advanced software to design robust QFT control systems
Software for analysis and simulation of dynamic systems
Multiple laboratory scale wind turbines with a variety of collinear and orthogonal rotors, electrical generators, gearboxes, sensors, actuators and hierarchical real-time torque/pitch/yaw control systems
Lab-scale wind farms with flexible configurations
Fully-controlled 6-DOF Stewart platform for lab-scale Floating Wind Turbine experimentation
Laboratory helicopter to test advanced control systems

Electro-Ceramics for Sustainable Energy Solutions

Our research interests are on functional materials that actively contribute to the application (i.e. thermoelectrics and piezoelectrics), rather than passive materials that are generally structural in nature. We concentrate on two paths of research: (i) applying materials technology to real life applications and (ii) developing new materials for extreme environmental conditions. Our objective is to investigate fundamental sciences and develop next generation materials and devices that will integrate physics and materials with other engineering fields such as mechanical and electrical engineering.

Electronics Design Center

With roots dating to the 1950s, the Electronics Design Center is a multi-disciplinary educational and research center focusing on the applications of microfabrication processing to the advancement of chemical and biological micro-systems specializing in application-oriented electrochemical based biosensors.

Great Lakes Energy Institute

The Great Lakes Energy Institute at Case Western Reserve University connects faculty across the university to transition breakthrough research into worldwide impact. Since 2008, GLEI has helped catalyze a five-fold increase in energy research, won awards from many major federal (NSF, DOE, ARPA-E) and state (Ohio Third Frontier) awards, attracted over $80 million in gifts, worked with over 100 different industry partners, and encouraged multidisciplinary proposals from throughout the university. At the heart of these proposals and effort are over 90 engaged faculty, hailing from engineering, arts & sciences, management, and law.

Institute for Advanced Materials

The Institute for Advanced Materials (IAM) at Case Western Reserve University provides a hub for collaborations among the university’s researchers, private industry and government partners that drive innovation of new materials from ideas to proven models to marketable technology. Focusing in the areas of advanced fundamentals, energy, sustainability and materials for human health, IAM's nearly 100 faculty leverage their expertise in specialties ranging from ceramics and metals, semiconductors, composites, polymers, and biomedical materials including regenerative tissue engineering.

Larry Sears and Sally Zlotnick Sears think[box]

Sears think[box], the university’s seven-story, 50,000-square-foot innovation center gives the campus community the room and tools it needs to test and tinker, to collaborate and fabricate, and to bring ideas to life. Students, faculty, staff and community members have access to a variety of equipment"from rapid prototyping tools like 3-D printers to CNC machining equipment like PCB routers and laser cutters"as well as to collaborative design space, and entrepreneurial resources.

Magnetic Materials Characterization Laboratory

This laboratory has world class magnetometry facilities and unique measurement capabilities to aid in materials discovery and general magnetic material investigations. A Lakeshore Model 7410 Vibrating Sample Magnetometer with high temperature furnace capability enables the measurement of quasi-static hysteresis loops, thermomagnetic measurements, and various other magnetic materials analyses. We can measure powders, thin films, and bulk samples in fields up to 3.1 Tesla at room temperature or 2.3 Tesla with the oven inserted. A magnetostriction characterization facility using strain gauges provides accurate shape change better than 1 ppm sensitivity at room temperature and fixed field (~0.2 T). Other measurement capabilities are in progress, including measurement of AC core losses.

Materials for Opto/Electronics

The MORE Center advances science and innovation with facilities enabling the fabrication and characterization of materials and devices for solar energy and emerging electronic and optoelectronic technologies.

Microfabrication Laboratory

The Microfabrication Laboratory (MFL) is a state-of-the-art, Class 100 cleanroom configured for the fabrication of micro- and nanoelectromechanical systems. Capabilities include thin film deposition, photolithographic patterning, reactive ion etching, and wafer bonding. Materials processed in the MFL include semiconductors, ceramics, metals and polymers. The laboratory is known for its support of world class research in silicon carbide MEMS. Laboratories affiliated with the MFL support design, packaging and testing of the devices fabricated in the facility.

Neural Engineering Center

The Neural Engineering Center (NEC) is a coordinated group of scientists and engineers dedicated to research and education in an area at the interface between neuroscience and engineering. They share the common goal of analyzing the function of the nervous system, developing methods to restore damaged neurological function, and interfacing with the nervous system to obtain information and to modulate neural activity. This is achieved by integrating physical, chemical, mathematical, biological and engineering tools.

Nitinol Commercialization Accelerator

The Ohio Third Frontier Wright Projects Program has funded a collaborative effort between the Cleveland Clinic, CWRU, University of Toledo, NASA Glenn Research Center, and Norman Noble, Inc. in order to develop a better understanding of the metallurgical processing and mechanical characterization of nitinol for use in biomedical and aerospace applications. Biomedical applications range from orthodontia to implantable devices while higher temperature shape memory alloys are of interest for aerospace. The collaboration is designed to create synergy amongst collaborators in the research and development of nitinol products. CWRU has developed a facility wherein the effects of composition changes on mechanical performance can be determined. The laboratory housed at CWRU’s Materials Science and Engineering Department contains processing and characterization (thermal and mechanical) equipment that allows for the manufacture and analysis of nitinol products. The CWRU campus community can access the facility via the use of a valid CWRU university account number that will be charged at an internal rate for machine time, including set up and any technician time involved. Long term testing can be provided at pro-rated charges in consultation with the laboratory director(s). Arrangements can be made to train users on the equipment and reserve time for equipment use. Outside (i.e. non-CWRU) users can access the facility via a number of different mechanisms by contacting the laboratory director(s).

Rapid Solidification Laboratory

The Rapid Solidification Laboratory has a single wheel melt spinner capable of producing alloy in a clean manufacturing environment. Alloys produced at the maximum quench rate by this process consist of 20 micron thick ribbons which can be made amorphous depending on quench rate and compositions are suitably chosen.

SDLE Research Center

The SDLE Research Center at Case Western Reserve University (CWRU) is a world-class research center dedicated to data science and analytics applied to materials and energy science.

Established in 2011 by Professor Roger H French, the SDLE Center focuses on
- Lifetime and degradation science of solar photovoltaic (PV) materials, and other environmentally exposed, long lived (>25 years) technologies.
- Accelerated laboratory and outdoor real-world exposures and evaluations of outdoor exposed technologies such as solar, led lighting and building envelope materials
- Energy efficiency and virtual energy auditing of buildings, using engineering epidemiology and data analytics
- Data-mining and statistical- and machine-learning applied to materials
- Petabyte/Petaflop big data analytics applied to time-series, spectral and image datasets
- Non-relational data warehousing and analytics environment for complex systems.

Swagelok Center for Surface Analysis of Materials

The Swagelok Center for Surface Analysis of Materials (SCSAM) is a multi-user facility providing major instrumentation for materials microcharacterization, including high-resolution imaging, spatially resolved chemical analysis, and diffractometry.

The Institute for Management and Engineering

The Institute for Management and Engineering, or TIME, is a unique joint program between the schools of engineering and management. Upon completion of this highly selective one-year program, students who hold an undergraduate degree in engineering receive a master's in engineering and management. Students aspire to be business-minded engineers through studies that integrate the best engineering and management practices.

Wind Energy Research Center

The Wind Energy Research and Commercialization (WERC) Center is a multidisciplinary center for use by students, faculty, and industry providing instrumentation for wind resource characterization and research platforms in operating wind turbines. The WERC Center was established in 2010 with funding from the Ohio Department of Development Third Frontier Wright Project and the Department of Energy.

The instruments in the WERC Center include:

**A NorthWind 100 wind turbine manufactured by Northern Power Systems. This 100kW community-scale wind turbine has a direct drive generator with full power inverters, stall control blades with a 21 m rotor diameter, and a 37 m hub height. It is located on campus just east of Van Horn field and began operation in November, 2010.
**A Vestas V-27 wind turbine originally manufactured by Vestas. This 225kW medium-scale wind turbine has a gearbox drive generator, pitch controlled blades with a 27 m rotor diameter, and a 30 m hub height. In addition it has a 50kW generator for low wind generation. It is located at an industrial site in Euclid, OH about 15 minutes from campus.
**A Nordex N-54 wind turbine originally manufactured by Nordex. This 1.0MW utility-scale wind turbine has a gearbox drive generator, stall control blades with a 54 m rotor diameter, and a 70 m hub height. In addition it has a 200kW generator for low wind generation. This wind turbine is located at an industrial site in Euclid, OH about 15 minutes from campus.
**A continuous scan ZephIR LiDAR, manufactured by Natural Power. This instrument measures horizontal and vertical wind velocity along with wind direction at 1 Hz frequency at five user set heights up to 200 m.
**Five meteorological measurement systems: 3 on campus; 1 with the off-campus wind turbines; and one at the City of Cleveland’s water intake crib located 3.5 miles offshore in Lake Erie.

Yeager Center for Electrochemical Sciences

The Yeager Center for Electrochemical Sciences (YCES) is an internationally recognized research center dedicated to advances in all aspects of electrochemical sciences and electrochemical systems and devices. YCES fosters education and research among many disciplines at Case Western Reserve.